Enantioselective Synthesis of Chiral Tripodal Cage Compounds by [2 + 2 + 2] Cycloaddition of Branched Triynes
2009-09-03T00:00:00Z (GMT) by
Cyclotrimerization of triynes branched by a nitrogen atom of 2-aminophenol yielded planar-chiral tripodal cage compounds. When a cationic Rh−Me-DUPHOS catalyst was used, the cycloadducts were obtained in high yield and excellent ee, and a macrocyclic compound with a cyclophane system was also obtained. This method can be further applied to the synthesis of a triarmed pyridinophane by the intramolecular reaction of a diyne−nitrile.
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