Enantioselective Sequential Conjugate Addition−Allylation Reactions: A Concise Total Synthesis of (+)-Podophyllotoxin
2009-02-05T00:00:00Z (GMT) by
A highly flexible and concise total synthesis of (+)-podophyllotoxin featured with an enantioselective sequential conjugate addition-allylation reaction was reported. Starting from commercially available 3,4,5-trimethoxycinnamic acid, this new route leads to (+)-podophyllotoxin <b>1</b> in only eight steps with 29% overall yield.
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