ol8b04143_si_001.pdf (8.65 MB)
Enantioselective Ir-Catalyzed Allylic Alkylation of Racemic Allylic Alcohols with Malonates
journal contribution
posted on 2019-01-23, 21:19 authored by Chun-Yan Meng, Xiao Liang, Kun Wei, Yu-Rong YangIr-catalyzed enantioselective
allylic alkylation of branched racemic
allylic alcohols with malonates is described. Enabled by Carreira’s
chiral Ir/(P, olefin) complex, the method described allows allylic
substitution with various aromatic alcohols and malonates with excellent
enantioselectivity. The malonates could be used directly as efficient
nucleophiles without the need of preactivation.