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Enantioselective Ir-Catalyzed Allylic Alkylation of Racemic Allylic Alcohols with Malonates

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journal contribution
posted on 2019-01-23, 21:19 authored by Chun-Yan Meng, Xiao Liang, Kun Wei, Yu-Rong Yang
Ir-catalyzed enantioselective allylic alkylation of branched racemic allylic alcohols with malonates is described. Enabled by Carreira’s chiral Ir/(P, olefin) complex, the method described allows allylic substitution with various aromatic alcohols and malonates with excellent enantioselectivity. The malonates could be used directly as efficient nucleophiles without the need of preactivation.

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