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Enantioselective Halocyclization Using Reagents Tailored for Chiral Anion Phase-Transfer Catalysis

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posted on 2012-08-08, 00:00 authored by Yi-Ming Wang, Jeffrey Wu, Christina Hoong, Vivek Rauniyar, F. Dean Toste
A chiral anion phase-transfer system for enantioselective halogenation is described. Highly insoluble, ionic reagents were developed as electrophilic bromine and iodine sources, and application of this system to o-anilidostyrenes afforded halogenated 4H-3,1-benzoxazines with excellent yield and enantioselectivity.

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