ja305795x_si_004.cif (42.93 kB)
Enantioselective Halocyclization Using Reagents Tailored for Chiral Anion Phase-Transfer Catalysis
dataset
posted on 2012-08-08, 00:00 authored by Yi-Ming Wang, Jeffrey Wu, Christina Hoong, Vivek Rauniyar, F. Dean TosteA chiral anion phase-transfer system for enantioselective
halogenation
is described. Highly insoluble, ionic reagents were developed as electrophilic
bromine and iodine sources, and application of this system to o-anilidostyrenes afforded halogenated 4H-3,1-benzoxazines with excellent yield and enantioselectivity.