ol8b01597_si_001.pdf (15.84 MB)
Enantioselective Cobalt-Catalyzed Sequential Nazarov Cyclization/Electrophilic Fluorination: Access to Chiral α‑Fluorocyclopentenones
journal contribution
posted on 2018-06-20, 13:54 authored by Heyi Zhang, Biao Cheng, Zhan LuA newly
designed thiazoline iminopyridine ligand for enantioselective
cobalt-catalyzed sequential Nazarov cyclization/electrophilic fluorination
was developed. Various chiral α-fluorocyclopentenones were prepared
with good yields and diastereo- and enantioselectivities. Further
derivatizations could be easily carried out to provide chiral cyclopentenols
with three contiguous stereocenters. Furthermore, a direct deesterification
of fluorinated products could afford chiral α-single fluorine-substituted
cyclopentenones.