ol1005104_si_001.pdf (2.32 MB)
Enantioselective α-Amination of 1,3-Dicarbonyl Compounds Using Squaramide Derivatives as Hydrogen Bonding Catalysts
journal contribution
posted on 2010-05-07, 00:00 authored by Hideyuki Konishi, Tin Yiu Lam, Jeremiah P. Malerich, Viresh H. RawalCatalytic enantioselective α-hydrazination of 1,3-dicarbonyl compounds with azodicarboxylates was investigated in the presence of our newly developed hydrogen bonding catalyst, squaramide 3j. High yields and high enantioselectivities were achieved with low catalyst loading under mild conditions.