cs400594e_si_002.pdf (2.96 MB)
Enantioselective Addition of Thiols to Imines Catalyzed by Thiourea–Quaternary Ammonium Salts
journal contribution
posted on 2013-10-04, 00:00 authored by Hong-Yu Wang, Jia-Xing Zhang, Dong-Dong Cao, Gang ZhaoAsymmetric
phase-transfer catalysis was first applied to the synthesis
of chiral N,S-acetals by using amino acid-based bifunctional thiourea-ammonium
salt catalysts. The reaction could be performed on the gram scale
to give up to 93% ee and 99% yield with a catalyst loading as low
as 0.1 mol % within 5 min.