jo2018735_si_001.pdf (6.82 MB)
Electroreductive Intramolecular Coupling of Phthalimides with Aromatic Aldehydes: Application to the Synthesis of Lennoxamine
journal contribution
posted on 2016-02-22, 12:32 authored by Naoki Kise, Shinsaku Isemoto, Toshihiko SakuraiThe electroreductive intramolecular coupling of phthalimides
with
aromatic aldehydes in the presence of chlorotrimethylsilane and triethylamine
led to five-, six-, and seven-membered cyclized products (58–84%).
The electroreductive cyclization was applied to the total synthesis
of lennoxamine.