Efficient Microwave-Assisted Synthesis of Amine-Substituted Tetrakis(pentafluorophenyl)porphyrin

We report an efficient and rapid means for the synthesis of tetrakis(pentafluorophenyl)porphyrin (TPPF<sub>20</sub>) derivatives by microwave irradiation in an environmentally acceptable solvent. The selective displacement of the <i>para</i>-fluorine groups in TPPF<sub>20</sub> by primary amines occurs in yields between 70 and 95%. This method demonstrates that TPPF<sub>20</sub> is an ideal platform for the rapid formation of porphyrin conjugates for therapeutic, catalytic, and other applications.