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Efficient Gold(I) Acyclic Diaminocarbenes for the Synthesis of Propargylamines and Indolizines
journal contribution
posted on 2018-08-23, 15:20 authored by Mélanie Aliaga-Lavrijsen, Raquel P. Herrera, M. Dolores Villacampa, M. Concepción GimenoMononuclear gold(I) acyclic diaminocarbenes
(ADCs) were prepared
by the reaction of 1,2-cyclohexanediamine with the corresponding isocyanide
complexes [AuCl(CNR)] (R = Cy, tBu). The
three-component coupling of aldehydes, amines, and alkynes was investigated
by using these gold(I) ADC complexes. The new gold(I) metal complexes
are highly efficient catalysts for the synthesis of propargylamines
and indolizines in the absence of solvent and in mild conditions.
This method affords the corresponding final products with excellent
yields in short reaction times. Additionally, chiral gold(I) complexes
with ADCs have been prepared and tried in the enantioselective synthesis
of propargylamines.