la060280h_si_001.avi (277.28 kB)
Effect of an Oscillating Magnetic Field on the Release Properties of Magnetic Collagen Gels
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posted on 2006-06-20, 00:00 authored by Vania M. De Paoli, Silvia H. De Paoli Lacerda, Leonard Spinu, Bruce Ingber, Zeev Rosenzweig, Nitsa RosenzweigThe paper describes the effect of an oscillating magnetic field (OMF) on the morphology and release properties
of collagen gels containing magnetic nanoparticles and microparticles and fluorescent drug analogues. Collagen gels
were prepared through fibrillogenesis of collagen in the presence of iron oxide magnetic particles averaging 10 nm
or 3 μm in diameter and rhodamine-labeled dextran (Dex-R) of molecular weights between 3000−70 000 g/mol.
Dextran molecules effectively simulate protein-based drugs, since they have similar molecular weights and dimensions.
The paper discusses the effect of an OMF on the release properties of the gels and proposes an empirical model to
predict the release rate. It also demonstrates the self-repair capability of collagen gels following the structural damage
caused by an OMF.