bm9b01290_si_001.pdf (1.34 MB)
Dynamic-Covalent Hydrogel with NIR-Triggered Drug Delivery for Localized Chemo-Photothermal Combination Therapy
journal contribution
posted on 2019-12-12, 17:37 authored by Pengfei Sun, Ting Huang, Xiaoxiao Wang, Gaina Wang, Zhijia Liu, Guosong Chen, Quli FanNear-infrared (NIR) light-responsive, injectable hydrogels
are
among the most promising drug delivery systems for localized anticancer
therapy owing to its minimally invasive administration and remote-controlled
manner. However, most currently reported NIR-responsive hydrogels
were usually generated through physical mixing of thermosensitive
polymers and photothermal conversion agents. In this study, a novel
type of dynamic-covalent hydrogel (GelPV-DOX-DBNP) with NIR light-triggered
drug release behavior was rationally designed for chemo-photothermal
combination treatment of tumors. Concretely, this NIR-responsive hydrogel
was formed by specific benzoxaborole-carbohydrate interactions between
benzoxaborole (BOB)-modified hyaluronic acid (BOB-HA) and fructose-based
glycopolymer (PolyFru), where photosensitizer perylene diimide zwitterionic
polymer (PDS), reductant ascorbic acid (Vc), anticancer drug doxorubicin
(DOX) as well as photothermal nanoparticles (DB-NPs) were encapsulated,
simultaneously. Upon 660 nm light irradiation, both PDS and Vc within
the designed hydrogel can convert oxygen into hydrogen peroxide, which
could make hydrogel be degraded through the breakage of dynamic covalent
bonds based on benzoxaborole-carbohydrate interactions, leading to
NIR light-activatable release of DOX and DB-NPs from GelPV-DOX-DBNP.
Furthermore, the released DB-NPs can convert 915 nm light irradiation
into heat, enabling the application of GelPV-DOX-DBNP as a NIR-responsive
drug delivery platform for both chemotherapy and photothermal therapy
(PTT). In vivo results prove that GelPV-DOX-DBNP exhibited a markedly
enhanced chemo-photothermal synergistic therapy for 4T1 tumor model
mice, compared to chemotherapy alone or PTT. This work presents a new strategy to construct NIR light-responsive
hydrogel as one alternative drug delivery system for anticancer applications.
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BOBphotothermal conversion agentstherapyPTTBOB-HA660 nm light irradiationbenzoxaborole-carbohydrate interactions4 T 1 tumor model micechemo-photothermal combination treatmentphotosensitizer perylene diimide zwitterionic polymerDOXNIR light-activatable releaseNIR-Triggered Drug DeliveryPDSalternative drug delivery system915 nm light irradiationGelPV-DOX-DBNPNIR light-triggered drug release behaviorNIR-responsive drug delivery platformDB-NPdrug delivery systemsLocalized Chemo-Photothermal Combination Therapy Near-infraredNIR light-responsive hydrogelanticancer
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