Dual Catalytic Platform for Enabling sp3 α C–H Arylation and Alkylation of Benzamides

Rand, Alexander
W.; Yin, Hongfei; Xu, Liang; Giacoboni, Jessica; Martin-Montero, Raul; Romano, Ciro; Montgomery, John; Martin, Ruben

doi:10.1021/acscatal.0c01318.s002

cs0c01318_si_002.pdf (4.14 MB)

Dual Catalytic Platform for Enabling sp³ α C–H Arylation and Alkylation of Benzamides

journal contribution

posted on 2020-04-01, 19:42 authored by Alexander W. Rand, Hongfei Yin, Liang Xu, Jessica Giacoboni, Raul Martin-Montero, Ciro Romano, John Montgomery, Ruben Martin

A dual catalytic sp³ α C–H arylation and alkylation of benzamides with organic halides is described. This protocol exhibits an exquisite site selectivity, chemoselectivity, and enantioselectivity pattern, offering a complementary reactivity mode to existing sp³ arylation or alkylations via transition metal catalysis or photoredox events.