Domperidone Solubility in
Aqueous Cosolvent Mixtures of N,N‑Dimethylformamide, Isopropanol, Dimethyl Sulfoxide,
and Ethanol: Thermodynamic Modeling and Preferential Solvation Analysis
posted on 2019-06-21, 19:13authored byQiong He, Min Zheng, Hongkun Zhao
The determination
of solubility of domperidone in aqueous cosolvent
mixtures of isopropanol, N,N-dimethylformamide
(DMF), dimethyl sulfoxide (DMSO), and ethanol was carried out by a
shake-flask method over the temperatures from 293.15 to 333.15 K under
local atmospheric pressure p = 101.1 kPa. It may
be observed that the domperidone solubility increased and then decreased
as the mass fractions of DMF (DMSO, isopropanol, or ethanol) increased.
The maximum solubility data was found with the cosolvent composition
of 0.8 in mass fraction. The determined solubility values were correlated
using the Jouyban–Acree, van’t Hoff–Jouyban–Acree,
and Apelblat–Jouyban–Acree models. The attained average
relative deviations were smaller than 7.56%. Preferential solvation
analysis of domperidone was performed by the inverse Kirkwood–Buff
integral method. The preferential solvation parameters
(δx1,3) by the cosolvent showed
positive values in the composition regions of 0.20 < x1 < 0.50 for DMF, 0.24 < x1 < 0.55 for isopropanol, 0.20 < x1 < 0.45 for DMSO, and 0.24 < x1 < 0.61 for ethanol. Domperidone was solvated preferentially
by the cosolvents in these regions. We may conjecture that the drug
acts as a Lewis acid in the presence of isopropanol (DMF, DMSO, and
ethanol) molecules.