Divergent Enantioselective Synthesis of (Nor)illudalane Sesquiterpenes via Pd0‑Catalyzed Asymmetric C(sp3)–H Activation

A divergent enantioselective synthesis of (nor)­illudalane sesquiterpenes was designed by using a Pd0-catalyzed asymmetric C­(sp3)–H arylation as a key step to control the isolated, highly symmetric quaternary stereocenter of the target molecules. A matched combination of chiral substrate and catalyst proved optimal to reach good levels of stereoselectivity. This approach enabled the synthesis of three (nor)­illudalanes, including (S)-deliquinone and (S)-russujaponol F, which are synthesized for the first time in enantioenriched form.