ol503465p_si_002.pdf (3.96 MB)
Divergent Approach to Building a Latrunculin Family Derived Hybrid Macrocyclic Toolbox
journal contribution
posted on 2015-02-06, 00:00 authored by Madhu Aeluri, Bhanudas Dasari, Prabhat AryaA divergent
approach to obtain a latrunculin family based hybrid
macrocyclic toolbox is developed. A practical, stereoselective synthesis
of a common substructure present in latrunculin A and latrunculol
A was achieved. This was further utilized in the macrocyclic diversity
synthesis. The amino acid moiety embedded in the 15-membered macrocyclic
ring allows for the exploration of various chiral side chains as one
of the diversity sites.