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Diterpenes, Sesquiterpenes, and a Sesquiterpene−Coumarin Conjugate from Jatropha integerrima

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journal contribution
posted on 2009-11-30, 00:00 authored by Somyote Sutthivaiyakit, Wantana Mongkolvisut, Samran Prabpai, Palangpon Kongsaeree
Five new compounds, 2α-hydroxyjatropholone (1), 2β-hydroxyjatropholone (2), 1,5-dioxo-2,3-dihydroxyrhamnofola-4(10),6,11(18),15-tetraene (3), 2-keto-5-hydroxyguai-3,11-diene (4), and a sesquiterpene−coumarin conjugate, jatrophadioxan (5), and nine known compounds have been isolated from the roots of Jatropha integerrima. The structures were established from spectroscopic data, and the relative configuration of 1 was confirmed by X-ray crystallography. Six diterpenes were evaluated for their antiplasmodial, antituberculosis, and cytotoxic activities.

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