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Discovery and Preclinical Characterization of (+)-3-[4-(1- Piperidinoethoxy)phenyl]spiro[indene- 1,1‘-indane]-5,5‘-diol Hydrochloride: A Promising Nonsteroidal Estrogen Receptor Agonist for Hot Flush
journal contribution
posted on 2003-08-13, 00:00 authored by Nobuhide Watanabe, Akihisa Ikeno, Hisao Minato, Hiroshi Nakagawa, Chie Kohayakawa, Jun-ichi TsujiIn our studies of the development of a novel class
of selective estrogen receptor modulators, (+)-3-[4-(1-piperidinoethoxy)phenyl]spiro[indene-1,1‘-indane]-5,5‘-diol hydrochloride (1) was found to be an estrogen receptor ligand with
beneficial effects in rat models for human hot flush. Moreover,
1 was found to have beneficial effects on lipid and bone
metabolism while maintaining marginal effects on the uterus
and breasts. These findings suggest that 1 would provide a
new treatment for hot flush.