ol5b02891_si_001.pdf (3.09 MB)
Direct Catalytic Asymmetric Synthesis of β‑Hydroxy Acids from Malonic Acid
journal contribution
posted on 2015-12-18, 00:00 authored by Hang Gao, Zhenli Luo, Pingjin Ge, Junqian He, Feng Zhou, Peipei Zheng, Jun JiangA nickel(II) catalyzed asymmetric
synthesis of β-hydroxy
acids from malonic acid and ketones was developed, revealing for the
first time the synthetic utility of malonic acid in the construction
of chiral carboxyl acids; importantly, the synthetic potential of
this strategy was further demonstrated by the rapid construction of
cephalanthrin A, phaitanthrin B, cruciferane, and rice metabolites.