Direct α‑Arylation/Heteroarylation of 2‑Trifluoro­borato­chromanones via Photoredox/Nickel Dual Catalysis

Utilizing photoredox/nickel dual catalysis, diverse flavanones have been synthesized by coupling novel 2-trifluoro­borato­chromanone building blocks with aryl and heteroaryl bromide partners. The newly reported trifluoro­borato­chromanones can be easily accessed from the corresponding chromones on multigram scale. This represents a general route for accessing natural and unnatural flavanones that were previously formed through a synthetically more restrictive ring closure route from chalcone precursors.