Direct α‑Arylation/Heteroarylation of 2‑Trifluoro­borato­chromanones via Photoredox/Nickel Dual Catalysis

2017-01-11T22:13:23Z (GMT) by Jennifer K. Matsui Gary A. Molander
Utilizing photoredox/nickel dual catalysis, diverse flavanones have been synthesized by coupling novel 2-trifluoro­borato­chromanone building blocks with aryl and heteroaryl bromide partners. The newly reported trifluoro­borato­chromanones can be easily accessed from the corresponding chromones on multigram scale. This represents a general route for accessing natural and unnatural flavanones that were previously formed through a synthetically more restrictive ring closure route from chalcone precursors.