jo8b02943_si_001.pdf (1.39 MB)
Dinuclear Zinc-AzePhenol Catalyzed Asymmetric Aza-Henry Reaction of N‑Boc Imines and Nitroalkanes under Ambient Conditions
journal contribution
posted on 2019-02-01, 00:00 authored by Shanshan Liu, Wen-Chao Gao, Yu-Hang Miao, Min-Can WangThe asymmetric aza-Henry
reaction of N-Boc imines
and nitroalkanes was realized in the presence of 10 mol % dinuclear
zinc-AzePhenol catalysts under ambient conditions. A variety of nitroamines
were obtained in good yields (up to 97%) with excellent enantioselectivities
(up to 99% ee) and high diasteroselectivity (up to 14:1 dr).
Our protocol combined the operational simplicity and mild reaction
conditions, thus making the process amenable for technical applications.
History
Usage metrics
Categories
Keywords
applicationreaction conditionspresenceeenitroalkaneIminezinc-AzePhenolAmbient ConditionsvarietydiasteroselectivitydrenantioselectivitiedinuclearDinuclear Zinc-AzePhenol Catalyzed Asymmetric Aza-Henry Reactionaza-Henry reactionambient conditionscatalystmolnitroamineNitroalkaneyieldBoc iminessimplicity
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC