np200439n_si_001.pdf (3.83 MB)
Dimeric ent-Kaurane Diterpenoids from Isodon excisus
journal contribution
posted on 2011-11-28, 00:00 authored by Seong
Su Hong, Seon A Lee, Chul Lee, Xiang Hua Han, Sanggil Choe, Nahyun Kim, Dongho Lee, Chong-Kil Lee, Youngsoo Kim, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon HwangFive new dimeric ent-kauranoids, biexcisusins
A–E (1–5), were isolated from
the aerial parts of Isodon excisus. The structures
and relative configurations of these compounds were determined on
the basis of spectroscopic data interpretation. Of these, biexcisusins
C–E (3–5) are dimeric ent-kaurane diterpenoids exhibiting an unprecedented linkage
through a nine-membered lactone ring between two ent-kaurane subunits. Compounds 1–5 showed no inhibitory effects on the LPS-induced production of nitric
oxide in murine macrophage RAW264.7 cells, up to a dose of 50 μM.