jo7b01855_si_003.cif (362.31 kB)
Diastereoselective Synthesis of Functionalized Diketopiperazines through Post-transformational Reactions
dataset
posted on 2017-10-19, 00:00 authored by Saeed Balalaie, Reihaneh Ramezani Kejani, Elmira Ghabraie, Fatemeh Darvish, Frank Rominger, Fatima Hamdan, Hamid Reza BijanzadehA diversity-oriented access to diastereoselective
arylidene 2,5-diketopiperazines
is elaborated via a sequential Ugi post-transformation involving catalytic
cyclization and oxidative Heck reaction sequence. This sequence offers
an interesting multicomponent entry to a library of 2,5-diketopiperazines
and arylidene 2,5-diketopiperazines under mild reaction conditions
in good to excellent yields.