ol101034s_si_002.pdf (1.77 MB)
Diastereoselective Syntheses of Functionalized Five-Membered Carbocycles and Heterocycles by a SmI2-Promoted Intramolecular Coupling of Bromoalkynes and α,β-Unsaturated Esters
journal contribution
posted on 2010-07-02, 00:00 authored by Kazunori Takahashi, Toshio HondaAn intramolecular coupling of bromoalkynes with α,β-unsaturated esters afforded functionalized five-membered carbocycles and heterocycles with high diastereoselectivities in excellent yields. The vinyl bromides newly generated as the products serve as adequate intermediates for further chemical modification.