ol0494515_si_002.pdf (76.66 kB)
Development of Chiral Pincer Palladium Complexes Bearing a Pyrroloimidazolone Unit. Catalytic Use for Asymmetric Michael Addition
journal contribution
posted on 2004-05-27, 00:00 authored by Kazuhiro Takenaka, Yasuhiro UozumiNovel pincer palladium complexes having chiral hexahydro-1H-pyrrolo[1,2-c]imidazolone groups were designed and prepared. Catalytic asymmetric
Michael addition of isopropyl 2-cyanopropionate to ethyl vinyl ketone was catalyzed by the chiral pincer palladium complex to give isopropyl
2-cyano-2-methyl-5-oxoheptanoate with high enantioselectivity (up to 83% ee).