nl4015233_si_001.pdf (2.57 MB)
Detection of a Few Metallo-Protein Molecules Using Color Centers in Nanodiamonds
journal contribution
posted on 2016-02-19, 03:58 authored by A. Ermakova, G. Pramanik, J.-M. Cai, G. Algara-Siller, U. Kaiser, T. Weil, Y.-K. Tzeng, H. C. Chang, L. P. McGuinness, M. B. Plenio, B. Naydenov, F. JelezkoNanometer-sized
diamonds containing nitrogen-vacancy defect centers
(NV) are promising nanosensors in biological environments due to their
biocompatibility, bright fluorescence, and high magnetic sensitivity
at ambient conditions. Here we report on the detection of ferritin
molecules using magnetic noise induced by the inner paramagnetic iron
as a contrast mechanism. We observe a significant reduction of both
coherence and relaxation time due to the presence of ferritin on the
surface of nanodiamonds. Our theoretical model is in excellent agreement
with the experimental data and establishes this method as a novel
sensing technology for proteins.