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Design of a Multifunctional Biomaterial Inspired by Ancient Chinese Medicine for Hair Regeneration in Burned Skin
journal contribution
posted on 2020-03-10, 11:39 authored by Zhaowenbin Zhang, Qiuxia Dai, Yu Zhang, Hui Zhuang, Endian Wang, Qing Xu, Lingling Ma, Chengtie Wu, Zhiguang Huan, Feng Guo, Jiang ChangIn deep
burn injuries, the dermis of the skin is often severely damaged, and
hair follicles are also lost and lose the potential for regeneration.
Therefore, the development of wound dressings that promote hair follicle
regeneration has important clinical significance. In this study, inspired
by an ancient Chinese medicine prescription, a novel fibrous membrane
(P/Qu/Cup; P, PCL; Qu, quercetin; Cup, cuprorivaite, CaCuSi4O10) containing quercetin-copper (Qu-Cu) chelates was
fabricated by using quercetin and a highly bioactive bioceramic (CaCuSi4O10) incorporated in PCL/gelatin electrospun fibers.
The fibrous membrane can effectively release Qu and Cu ions to induce
proliferation, migration, and differentiation of skin and hair follicle
related cells, and the Qu, Cu ions, and Si ions released from the
composite membrane revealed synergistic activity to stimulate hair
follicle regeneration and wound healing. Our study demonstrated that
the analysis of the common components in ancient Chinese prescription
is an effective approach to design novel bioactive materials for regenerative
medicine.