jo9b02318_si_001.pdf (6.66 MB)
Decarboxylative Alkylation of Heteroarenes Using N‑Hydroxybenzimidoyl Chloride Esters
journal contribution
posted on 2019-10-18, 12:05 authored by Xiaojuan Li, Qiang Zhang, Weigang Zhang, Yi Wang, Yi PanFunctionalized N-heteroarenes are highly desired
motifs in medicinal chemistry and pharmaceutical industry. Minisci-type
reactions usually require a protonated N-heteroarene
for the alkyl radical to attack. This work describes a leaving-group-assisted
redox-active ester to enable direct coupling of an amino acid with N-heteroarenes. The efficient and sustainable photoredox
strategy provides rapid access to an alkylated heterocyclic manifold.