Dabco as an Inexpensive and Highly Efficient Ligand for Palladium-Catalyzed Suzuki−Miyaura Cross-Coupling Reaction

2004-08-05T00:00:00Z (GMT) by Jin-Heng Li Wen-Jie Liu
An inexpensive and highly efficient Pd(OAc)2/Dabco catalytic system has been developed for the cross-coupling of aryl halides with arylboronic acids. A combination of Pd(OAc)2 and Dabco (triethylenediamine) was observed to form an excellent catalyst, which affords high TONs (turnover numbers; TONs up to 950 000 for the reaction of PhI and p-chlorophenylboronic acid) for Suzuki−Miyaura cross-coupling of various aryl iodides and bromides with arylboronic acids.