nl9b02565_si_001.pdf (1.88 MB)
DNA-Assembled Multilayer Sliding Nanosystems
journal contribution
posted on 2019-08-28, 14:04 authored by Pengfei Zhan, Steffen Both, Thomas Weiss, Na LiuDNA nanotechnology
allows for the realization of complex nanoarchitectures
in which the spatial arrangements of different constituents and most
functions can be enabled by DNA. When optically active components
are integrated in such systems, the resulting nanoarchitectures not
only provide great insights into the self-assembly of nanoscale elements
in a systematic way but also impart tailored optical functionality
to DNA origami. In this Letter, we demonstrate DNA-assembled multilayer
nanosystems, which can carry out coordinated and reversible sliding
motion powered by DNA fuels. Gold nanoparticles cross-link DNA origami
filaments to define the configurations of the multilayer nanoarchitectures
as well as to mediate relative sliding between the neighboring origami
filaments. Meanwhile, the gold nanoparticles serve as optical probes
to dynamically interact with the fluorophores tethered on the filaments,
rendering in situ detection of the stepwise sliding processes possible.
This work seeds the basis to implement DNA-assembled complex optical
nanoarchitectures with programmability and addressability, advancing
the field with new momentum.