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Cytotoxic Diterpenoids from the Soft Coral Sarcophyton crassocaule
journal contribution
posted on 2006-10-27, 00:00 authored by Cuixian Zhang, Jun Li, Jingyu Su, Yongju Liang, Xiaoping Yang, Kangcheng Zheng, Longmei ZengFive new cembrane diterpenoids, sarcrassins A−E (1−5) along with a known compound, emblide (6), have been isolated
from the soft coral Sarcophyton crassocaule collected from the Bay of Sanya, Hainan Island, China. The structures of
1−5 were determined by spectroscopic methods including 1D and 2D NMR techniques. Their relative configurations
were determined by NMR data and NOESY experiments. Compounds 2, 4, and 6 exhibited significant cytotoxic activities
against KB cell lines with IC50 values of 5.0, 4.0, and 5.0 μg/mL, respectively, while compounds 1 and 5 showed
moderate cytotoxicity toward KB cell lines with IC50 values of 19.0 and 13.0 μg/mL, respectively.
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cytotoxic activitiesHainan Islandsarcrassin19.05.013.0Sarcophyton crassocauleKB cell linesCompoundIC 50 valuesemblidecytotoxicitycompounds 1Sanyacembrane diterpenoidsNOESY experimentsCytotoxic Diterpenoids1 DconfigurationSoft Coral Sarcophyton crassocauleFivespectroscopic methods2 D NMR techniquesNMR data
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