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Cytotoxic Diarylheptanoids from the Roots of Juglans mandshurica

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posted on 2002-09-18, 00:00 authored by Kyung-Seon Lee, Gao Li, Sung Hwan Kim, Chong-Soon Lee, Mi-Hee Woo, Seung-Ho Lee, Yurng-Dong Jhang, Jong-Keun Son
A new (2) and three known diarylheptanoids (1, 3, and 4), along with one known sesquiterpenoid (5), were isolated from the roots of Juglans mandshurica, and their structures were elucidated on the basis of spectroscopic studies. Four of these compounds (25) exhibited moderate cytotoxicities against human colon carcinoma and human lung carcinoma cell lines with IC50's ranging from 2 to 25 μg/mL.

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