Cytochathiazines A–C: Three Merocytochalasans
with a 2H‑1,4-Thiazine Functionality from
Coculture of Chaetomium globosum and Aspergillus
flavipes

Wang, Wenjing; Zeng, Fanrong; Bie, Qiong; Dai, Chong; Chen, Chunmei; Tong, Qingyi; Liu, Junjun; Wang, Jianping; Zhou, Yuan; Zhu, Hucheng; Zhang, Yonghui

doi:10.1021/acs.orglett.8b02942.s001

ol8b02942_si_001.pdf (5.59 MB)

Cytochathiazines A–C: Three Merocytochalasans with a 2H‑1,4-Thiazine Functionality from Coculture of Chaetomium globosum and Aspergillus flavipes

journal contribution

posted on 2018-10-15, 20:31 authored by Wenjing Wang, Fanrong Zeng, Qiong Bie, Chong Dai, Chunmei Chen, Qingyi Tong, Junjun Liu, Jianping Wang, Yuan Zhou, Hucheng Zhu, Yonghui Zhang

Cytochathiazines A–C (1–3), which represent a new type of merocytochalasan, were isolated from coculture of Chaetomium globosum and Aspergillus flavipes. Compounds 1–3 are the first natural products featuring an unprecedented 2H-1,4-thiazine functionality. Plausible biosynthetic pathways for 1–3 with a chaetoglobosin and a dipeptide as the main constitutional units were proposed. Compound 2 induced apoptosis in leukemia cells through the activation of caspase-3 and the degradation of poly ADP-ribose polymerase.