ol5004725_si_001.pdf (1.95 MB)
Cysteine Pseudoprolines for Thiol Protection and Peptide Macrocyclization Enhancement in Fmoc-Based Solid-Phase Peptide Synthesis
journal contribution
posted on 2015-12-17, 01:11 authored by Tobias
M. Postma, Fernando AlbericioContrary
to other studies, here we describe cysteine (Cys) pseudoproline-containing
peptides with short deprotection times in TFA. The deprotection times
fell in the same range as other protecting groups commonly used in
SPPS (e.g., 1–3 h). Moreover, when using Cys pseudoprolines
as peptide macrocyclization-enhancing moieties a considerable reduction
in reaction time was observed compared to a peptide containing trityl
protected Cys.