ol060289a_si_001.pdf (1.72 MB)
Cyclocarbopalladation of Alkynes: A Stereoselective Method for Preparing Dibenzoxapine Containing Tetrasubstituted Exocyclic Alkenes
journal contribution
posted on 2006-04-13, 00:00 authored by Hannah Yu, Rachel N. Richey, Matthew W. Carson, Michael J. CoghlanA palladium-catalyzed cascade carbometalation-cross coupling of alkyne route was developed for the preparation of tetrasubstituted exocyclic
alkenes with high stereo- and regiocontrol. The effectiveness of this novel methodology was demonstrated by the synthesis of a number of
dibenzoxapines in sufficient quantities to support their further development.