ab6b00315_si_001.pdf (4.13 MB)
Cyanine-Curcumin Assembling Nanoparticles for Near-Infrared Imaging and Photothermal Therapy
journal contribution
posted on 2016-09-12, 00:00 authored by Jianxu Zhang, Shi Liu, Xiuli Hu, Zhigang Xie, Xiabin JingNear-infrared
(NIR) imaging and photothermal therapy (PTT) based
on the multifunctional cyanine dyes has shown great promise for cancer
therapy. However, most of the PTT agents are often limited by low
drug loading, short circulation time, and low biocompatibility. Herein,
we developed cyanine-curcumin assembling nanoparticles (CCNPs) via
a single-step reprecipitation method. IR-780-C4 (Cyc4) was employed
as a photothermal and NIR imaging agent. Self-assembly of Cyc4 and
curcumin in aqueous solution could be performed in the absence of
surfactants or adjuvants, which is a simple and efficient way to fabricate
nanomedicine with high drug loading. Formed CCNPs showed monodispersity,
good stability in physiological conditions, and lower cytotoxicity.
Moreover, CCNPs possess the high loading (70%) of cyanine dyes and
a higher photothermal conversion efficacy than free Cyc4, which contribute
to a decrease in the application dosage of cyanine dyes in cancer
therapy. Importantly, CCNPs exhibited excellent NIR imaging capacity
and photothermal tumor ablation under laser irradiation in vitro and
in vivo. This work highlights the potential of using self-assembling
of drug molecules to develop functional nanoparticles for drug delivery
and cancer therapy.