ol016258r_si_001.pdf (59.26 kB)
CuI-Catalyzed Coupling Reaction of β-Amino Acids or Esters with Aryl Halides at Temperature Lower Than That Employed in the Normal Ullmann Reaction. Facile Synthesis of SB-214857
journal contribution
posted on 2001-07-14, 00:00 authored by Dawei Ma, Chengfeng XiaThe CuI-catalyzed coupling reaction of aryl halides with β-amino acids or β-amino esters is completed at 100 °C in 48 h, which indicates that
the structure of the β-amino acid has an accelerating effect for the Ullmann-type aryl amination reaction. This coupling reaction can be used
to prepare enantiopure N-aryl β-amino acids. An efficient synthetic route to SB214857, a potent GPIIb/IIIa receptor antagonist, is developed
using this method.