CsF-Catalyzed Transannulation Reaction of Oxazolones:
Diastereoselective Synthesis of Diversified trans-N‑(6-Oxo-1,4,5,6-tetrahydropyrimidin-5-yl)benzamides
with Arylidene Azlactones and Amidines

Parhizkar, Golnaz; Khosropour, Ahmad Reza; Mohammadpoor-Baltork, Iraj; Parhizkar, Elahehnaz; Amiri
Rudbari, Hadi

doi:10.1021/acscombsci.8b00027.s001

co8b00027_si_001.pdf (2.92 MB)

CsF-Catalyzed Transannulation Reaction of Oxazolones: Diastereoselective Synthesis of Diversified trans-N‑(6-Oxo-1,4,5,6-tetrahydropyrimidin-5-yl)benzamides with Arylidene Azlactones and Amidines

journal contribution

posted on 2018-04-24, 00:00 authored by Golnaz Parhizkar, Ahmad Reza Khosropour, Iraj Mohammadpoor-Baltork, Elahehnaz Parhizkar, Hadi Amiri Rudbari

A versatile and straightforward synthetic strategy for the construction of new tetrasubstituted 1,3-diazinones is described. The procedure is based on CsF-catalyzed, microwave-assisted, ring transformation reaction of arylidene azlactones with amidines. Moreover, this technique provides diversified trans-N-(6-oxo-1,4,5,6-tetrahydropyrimidin-5-yl)benzamides with a good antimicrobial activity.