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Crystal Landscape of Primary Aromatic Thioamides

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journal contribution
posted on 2014-06-04, 00:00 authored by Kevin S. Eccles, Robin E. Morrison, Anita R. Maguire, Simon E. Lawrence
The crystal landscape of a series of primary aromatic thioamides is described, displaying similar characteristic intermolecular hydrogen-bonding interactions in the solid state to those observed in their widely studied amide analogues, including R22(8) dimers and C(4) chains. In a number of cases, high Z′ values were observed in the structures. On the basis of the observed solid-state features, the thioamide functional group, which is a strong hydrogen-bond donor and moderate acceptor, offers considerable potential as a key moiety for crystal engineering.

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