cg7b01096_si_001.pdf (2.85 MB)
Crystal Engineering in Continuous Plug-Flow Crystallizers
journal contribution
posted on 2017-10-10, 00:00 authored by Maximilian
O. Besenhard, Peter Neugebauer, Otto Scheibelhofer, Johannes G. KhinastSize,
shape, and polymorphic form are the critical attributes of
crystalline particles and represent the major focus of today’s
crystallization process design. This work demonstrates how crystal
properties can be tuned efficiently in solution via a tubular crystallizer
that facilitates rapid temperature cycling. Controlled crystal growth,
dissolution, and secondary nucleation allow a precise control of the
crystal size and shape distribution, as well as polymorphic composition.
Tubular crystallizers utilizing segmented flow such as the one presented
in our work can provide plug flow characteristics, fast heating and
cooling, allowing for rapid changes of the supersaturation. This makes
them superior for crystal engineering over common crystallizers. Characterization
of particle transport, however, revealed that careful selection of
process parameters, such as tubing diameter, flow rates, solvents,
etc., is crucial to achieve the full benefits of such reactors.
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crystal propertiesplug flow characteristicspolymorphic compositionControlled crystal growthContinuous Plug-Flow Crystallizers Sizeparticle transportprocess parameterscrystal Engineeringshape distributiontemperature cyclingtubing diametercrystal sizepolymorphic formcrystal engineeringTubular crystallizersflow rates
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