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Corrosion Resistance and Biocompatibility Assessment of a Biodegradable Hydrothermal-Coated Mg–Zn–Ca Alloy: An in Vitro and in Vivo Study
journal contribution
posted on 2020-02-25, 18:44 authored by Zheng Xi, Yunfeng Wu, Shouyang Xiang, Chu Sun, Yongxuan Wang, Haiming Yu, Yu Fu, Xintao Wang, Jinglong Yan, Dewei Zhao, Yaming Wang, Nan ZhangA hydrothermal (HT) coating was applied
to the biomedical Mg–Zn–Ca
alloy surface by microarc oxidation (MAO) and heat treatment. Then,
the corrosion resistance and biocompatibility of the coated alloy
was evaluated in vitro and in vivo. The corrosion rate (CR) of HT-coated
implants was significantly lower in experiment. In addition, this
CR increased over time in vivo but was stable, albeit higher, in vitro.
The proliferation, adhesion, and live activity of bone marrow stem
cells (BMSCs) were significantly greater on the surface of the HT-coated
Mg alloy in vitro. Serum Mg2+ was always within the normal
range in rabbits with implants, although Ca2+ was higher
than normal for both uncoated and coated scaffolds. There were no
significant pathological effects on the main organs of alloy-implanted
rabbits compared with healthy animals. Thus, the HT coating significantly
improved the corrosion resistance and biocompatibility of the Mg–Zn–Ca
alloy.