Copper-Mediated Oxidative Coupling of Benzamides with
Maleimides via Directed C–H Cleavage

Miura, Wataru; Hirano, Koji; Miura, Masahiro

doi:10.1021/acs.orglett.5b01940.s001

ol5b01940_si_001.pdf (4.3 MB)

Copper-Mediated Oxidative Coupling of Benzamides with Maleimides via Directed C–H Cleavage

journal contribution

posted on 2015-08-21, 00:00 authored by Wataru Miura, Koji Hirano, Masahiro Miura

A Cu(OAc)₂/Cy₂NMe-mediated oxidative direct coupling of benzamides with maleimides has been developed. The aromatic C–H alkenylation with the aid of an 8-aminoquinoline-based bidentate directing group is followed by an intramolecular aza-Michael-type addition to form the isoindolone-incorporated spirosuccinimides, which are of potent interest in medicinal chemistry.