ol5024689_si_001.pdf (4.58 MB)
Copper(II)-Mediated O‑Arylation of Protected Serines and Threonines
journal contribution
posted on 2015-12-17, 04:41 authored by Mirna El Khatib, Gary A. MolanderAn
effective protocol toward the O-arylation of
β-hydroxy-α-amino acid substrates serine and threonine
has been developed via Chan–Lam cross-coupling. This Cu(II)-catalyzed
transformation involves benign open-flask conditions that are well-tolerated
with a variety of protected (Boc-, Cbz-, Tr-, and Fmoc-) serine and
threonine derivatives and various potassium organotrifluoroborates
and boronic acids.