Copper(II)-Mediated O‑Arylation of Protected Serines and Threonines

2015-12-17T04:41:26Z (GMT) by Mirna El Khatib Gary A. Molander
An effective protocol toward the O-arylation of β-hydroxy-α-amino acid substrates serine and threonine has been developed via Chan–Lam cross-coupling. This Cu­(II)-catalyzed transformation involves benign open-flask conditions that are well-tolerated with a variety of protected (Boc-, Cbz-, Tr-, and Fmoc-) serine and threonine derivatives and various potassium organotrifluoroborates and boronic acids.