ol5b02235_si_001.pdf (4.93 MB)
Copper-Catalyzed sp3 C–H Aminative Cyclization of 2‑Alkyl‑N‑arylbenzamides: An Approach for the Synthesis of N‑Aryl-isoindolinones
journal contribution
posted on 2015-09-18, 00:00 authored by Kanako Nozawa-Kumada, Jun Kadokawa, Takehiro Kameyama, Yoshinori KondoThe
synthesis of isoindolinones via copper-catalyzed sp3 C–H
functionalization of 2-alkyl-N-substituted
benzamides is described. This process does not require the preparation
of halogenated substitutes, expensive transition metals, or toxic
Sn or CO gas. This method provides an efficient approach to generate
various functionalized isoindolinones.