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Copper-Catalyzed Regioselective and Stereoselective Coupling of Grignard Reagents with Pent-1-en-4-yn-3-yl Benzoates: A Shortcut to (Z)-1,5-Disubstituted Pent-3-en-1-ynes from Accessible Starting Materials
journal contribution
posted on 2018-10-18, 00:00 authored by Fenglin Chen, Yanjiao Chen, Hongen Cao, Qing Xu, Lei YuCopper-catalyzed
coupling of Grignard reagents with pent-1-en-4-yn-3-yl
benzoates occurs regioselectively at the terminal alkenyl carbon rather
than the alkynyl site, leading to the stereoselective formation of
unexpected (Z)-1,5-disubstituted
pent-3-en-1-ynes without generation of the initially expected alkenyl
allene products. By using easily accessible starting materials, this
reaction can provide direct access to thermodynamically unfavorable Z-configured enynes, which widely exist in many bioactive
natural products, such as the anti-inflammatory components in henna.
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generation-3-enGrignard reagentsPent -1-en BenzoatesaccesshennaGrignard Reagentsalkynyl sitestereoselective formationmaterialCopper-Catalyzed RegioselectiveDisubstitutedalkenyl allene productsanti-inflammatory componentspent -1-en benzoatesShortcutMaterials Copper-catalyzedAccessibleStereoselectiveconfigured enynesdisubstitutedterminal alkenyl carbonbioactiveregioselectively
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