ol9b03400_si_001.pdf (4.26 MB)
Copper-Catalyzed Asymmetric Reduction of β,β-Disubstituted Alkenylboramides
journal contribution
posted on 2019-10-18, 14:04 authored by Yeji Park, Jaesook YunA highly enantioselective copper-catalyzed
reduction of β,β-disubstituted
alkenylboron compounds was developed using hydrosilane. The copper
hydride catalyst coordinated with chiral Josiphos ligand efficiently
discriminated β-geminal substituents to generate corresponding
β-chiral alkylboramides with excellent enantioselectivities
up to 99% ee. The enantioselective reduction protocol provides a facile
approach to β-chiral alkylboron compounds with less sterically
discriminating substituents and spans a wide substrate range including
aryl-substituted borylalkenes with effective functional group tolerance.