ol9b03468_si_001.pdf (17.96 MB)
Copper-Catalyzed Amino-oxymethylation of Ynamides with N,O‑Acetals
journal contribution
posted on 2019-10-28, 17:33 authored by Jianliang Yu, Guangyang Xu, Shengbiao Tang, Ying Shao, Jiangtao SunA copper-catalyzed
1,2-difunctionalization of ynamides has been
developed by using readily available N,O-acetals as the bifunctional reagents. Importantly, contrary to the
initially expected 1,2-oxy-aminomethylation reaction, an unprecedented
1,2-amino-oxymethylation has been observed. This reaction is atom-economical
and tolerates a broad substrate scope, affording the difunctionalization
products in good yield with unique Z configuration.