Copper-Catalyzed Amino-oxymethylation of Ynamides with N,O‑Acetals
2019-10-28T17:33:53Z (GMT) by
A copper-catalyzed 1,2-difunctionalization of ynamides has been developed by using readily available N,O-acetals as the bifunctional reagents. Importantly, contrary to the initially expected 1,2-oxy-aminomethylation reaction, an unprecedented 1,2-amino-oxymethylation has been observed. This reaction is atom-economical and tolerates a broad substrate scope, affording the difunctionalization products in good yield with unique Z configuration.
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