ol5008394_si_002.pdf (1.04 MB)
Convenient Synthesis of Triphenylphosphanylidene Spiro[cyclopentane-1,3′-indolines] and Spiro[cyclopent[2]ene-1,3′-indolines] via Three-Component Reactions
journal contribution
posted on 2014-05-16, 00:00 authored by Ying Han, Yin-Jian Sheng, Chao-Guo YanThree-component reactions of triphenylphosphine,
but-2-ynedioate,
and isatylidene malononitrile (ethyl cyanoacetate) in dimethoxyethane
resulted in triphenylphosphanylidene spiro[cyclopentane-1,3′-indolines]
in satisfactory yields. Furthermore, similar three-component reactions
of triphenylphosphine, hex-2-en-4-ynedioate, and isatylidene malononitrile
(ethyl cyanoacetate) afforded functionalized spiro[cyclopent[2]ene-1,3′-indolines]
in good yields.