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Construction of Erythrinane Skeleton via Pd(0)-Catalyzed Intramolecular Dearomatization of para-Aminophenols
journal contribution
posted on 2014-11-05, 00:00 authored by Ren-Qi Xu, Qing Gu, Wen-Ting Wu, Zhuo-An Zhao, Shu-Li YouA novel Pd(0)-catalyzed intramolecular
arylative dearomatization
of para-aminophenol derivatives is described. In
the presence of 1.25 mol % [Pd(C3H5)Cl]2 and 3.75 mol % RuPhos, the arylative dearomatization reaction
proceeds smoothly for a broad range of substrates, offering an efficient
synthetic route to erythrinane derivatives in excellent yields.