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Construction of 9H‑Pyrrolo[1,2‑a]indoles by a Copper-Catalyzed Friedel–Crafts Alkylation/Annulation Cascade Reaction

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journal contribution
posted on 2016-11-04, 00:00 authored by Yongqing Sun, Yu Qiao, Haiying Zhao, Baoguo Li, Shufeng Chen
An efficient and concise Cu­(OTf)2-catalyzed Friedel–Crafts alkylation/annulation cascade reaction of substituted indoles with 1,2-dicarbonyl-3-enes has been established. This reaction uses readily available starting materials and is operationally simple, thus representing a practical method for the construction of diverse 9H-pyrrolo­[1,2-a]­indoles bearing a carbonyl group.

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